Currently, each Atlan instance is capable of connecting to only one AzureAD tenant.
However, it's always best for us to have a better understanding of your setup and organizational structure (for example, Are your users currently assigned to separate tenants?), in order to assess use-cases.
Being that we are always looking for new ways to serve our customers' needs, it never hurts to ask-just raise a support ticket and we will be happy to assist you.